In addition, Fanning did voice-over work for four animated projects during this period, including voicing Satsuki in Disney's English language release of My Neighbor Totoro, a little girl in the Fox series Family Guy, and a young Wonder Woman in the episode "Kids Stuff" from Cartoon Network's Justice League Unlimited.In 2004, she made an appearance on season ten of the television series Friends, playing the role of Mackenzie, a young girl who is moving out of the house Monica and Chandler are buying.In 2001, Fanning was chosen to star opposite Sean Penn in the movie I Am Sam, the story of a mentally challenged man who fights for the custody of his daughter (played by Fanning).Her role in the film made Fanning the youngest person ever to be nominated for a Screen Actors Guild Award, being seven years of age at the time.In July, Fanning appeared on a short film titled Cutlass, one of Glamour's "Reel Moments" based on readers' personal essays. From September to the end of the year, Fanning filmed Push, which centers on a group of young American expatriates with telekinetic and clairvoyant abilities who hide from the Division (a U. government agency) in Hong Kong and band together to try to escape the control of the division.
A year later, she starred in two prominent films: playing the uptight child to an immature nanny played by Brittany Murphy in Uptown Girls, and as Sally in The Cat in the Hat.
Released in reverse order (War in June 2005 and Dreamer in the following October), both films were a critical success.
Fanning moved straight to another film without a break: Charlotte's Web, which she finished filming in May 2005 in Australia, and premiered on December 15, 2006.
However, when Dakota heard that she would be required to shave her head for the role, she dropped out of the film as then did Elle.
The two sisters were replaced; Abigail Breslin took on the lead role as Anna Fitzgerald, and Sofia Vassilieva was cast as Kate Fitzgerald.