This Research Topic will also explore the mechanisms by which brainstem diseases and disorders alter these behavioral states.
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A significant challenge for researchers is delineating the specific contributions of discrete brainstem nodes, pathways, and transmitter systems to behavioral state and motor regulation.
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Brainstem dysfunction can therefore dramatically alter behavioral state, including the synchronization of forebrain activity with appropriate motor outputs.
Damage, loss, or dysfunction of the brainstem nuclei controlling sleep-wake or motor behaviors is a key contributing etiology to the profound behavioral state and motor disturbances that pervade many neurodegenerative conditions.
This work was supported by a grant from the Simons Foundation (SFARI award #26021565-08C000066 to J. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A.
SSIB Career Awards are intended to honor the distinguished careers of those making significant contributions to the field of ingestive behavior.